How to determine Particle Size? There are different methods to determine the particle size of formulation. It is determined by light diffraction, dynamic light scattering, Coulter method etc.
Table of Content
What is Particle Size?
Particle size is a measure of the amount of space that a particle occupies. In other words, it is a measure of the physical dimensions of a particle. Particle size can be measured in terms of length, width, height, or diameter. Particle size is a measure of the dimensions of solid particles.
The most common method to determine particle size is sieve analysis. This technique uses a stack of sieves with progressively smaller mesh openings to separate the sample into fractions according to size. The mesh opening sizes in each sieve are chosen so that 50% or more of the sample falls through the largest mesh and 50% or less falls through the smallest mesh.
Methods to determine Particle Size
There are a few different methods that can be used to determine the particle size of formulation. One common method is to use a laser diffraction system, which uses laser light to measure the diffraction of the formulation. Another common method is to use an electron microscope, which can provide detailed images of the formulation. Finally, another popular method is to use a Coulter Counter, which uses an electrical field to measure the size of particles.
There are a variety of methods that can be used to determine particle size. Some common methods include sieving, sedimentation, light scattering, and electron microscopy.
Sieving is a common method used to determine particle size. This method involves passing a sample of the material through a series of mesh screens with progressively smaller openings. The mesh size that allows particles to pass through is recorded and this is used to calculate the particle size.
Sedimentation is another common method used to determine particle size. This method involves suspending the sample in a liquid and allowing the particles to settle out over time. The rate at which the particles settle is dependent on their size; larger particles will settle more quickly than smaller particles. The particle size can be calculated from the settling rate.
Light scattering techniques
Light scattering techniques can also be used to determine particle size. These techniques make use of the fact that when light encounters a particle, it is scattered in all directions. The amount of scattering depends on the size of the particle; larger particles will scatter more light than smaller particles.
Electron microscopy is another method that can be used to determine particle size. This method uses a beam of electrons to examine the sample. The electrons interact with the atoms in the sample and this interaction can be used to calculate the dimensions of the particles.
There are a variety of different light scattering techniques that can be used, including laser diffraction, dynamic light scattering, and static light scattering.
Particle size is an important property of materials and it can have a significant impact on the performance of the material. For example, smaller particles will have a larger surface area than larger particles. This means that they will interact more with their surroundings and they will be more reactive.
Particle size can also affect the way that a material flows. Smaller particles will flow more easily than larger particles. This property is known as fluidity.
finally, particle size can also affect the strength of a material. In general, smaller particles will have a higher surface area-to-volume ratio. This means that they will be weaker than larger particles.
Factors That Affect Particle Size
As you might expect, the size of a particles is determined by a number of factors. The primary factor is the manufacturing process used to create. Other important factors include the type of material from which the formulation are made and the desired properties of the finished product.
One way to control particle size is to use a process called emulsion polymerization. This process creates uniform spheres by suspending tiny droplets of monomer in water. The monomer then undergoes a chemical reaction to form polymer chains that link together to form a spherical shape. The droplets gradually grow larger as more monomer is added and eventually coalesce into larger spheres.
The size of the particles can also be controlled by varying the ratio of monomer to water. A higher ratio of monomer will result in smaller spheres, while a lower ratio will result in larger spheres. Additionally, the type of monomer used can also affect the size of the resulting formulation. Some monomers, such as styrene, will produce smaller spheres than other monomers, such as methyl methacrylate.
How to Use Particle Size Data
There are a number of ways to determine particle size of formulation. The most common method is to use a laser diffraction system. This system uses laser light to measure the diffraction of light off of the particles. The system then calculates the particle size based on the amount of diffraction.
Other methods for determining particle size include dynamic light scattering and microscopy. Dynamic light scattering measures the speed at which particles scatter light. This information can be used to calculate particle size. Microscopy involves looking at particles under a microscope and measuring them directly. This method is less common because it is more time-consuming and expensive.
The Different Methods for Determining Particle Size
There are many methods for determining the particle size of formulation, each with its own advantages and disadvantages. The most common methods are laser diffraction, dynamic light scattering (DLS), and electron microscopy (EM).
Laser diffraction is the most widely used method for measuring particle size, as it is quick and easy to set up and use. However, it is only able to measure sizes down to around 1 micrometer (μm), so smaller particles cannot be accurately measured with this method.
DLS is able to measure much smaller particles than laser diffraction, down to around 0.1 μm. However, it is more complex to set up and use, so it is not as popular as laser diffraction.
EM can measure particles down to around 0.01 μm, but it is very difficult to set up and use, so it is not often used for measuring particle size.
There are a few different ways to determine the particle size of formulation. The most common method is to use a laser diffraction instrument, which can provide accurate results for both larger and smaller particles. Other methods include using a sedimentation technique or a Coulter Counter. Whichever method you choose, it’s important to get accurate measurements during formulation and development so that you can create the perfect formulation for your needs.
- Understanding Cell Biology: An International Certificate Course
- Understanding ISO 13485: A Guide to Medical Device Quality Management Systems
- M. Pharm Thesis Topics for Pharmaceutics (Updated)
- M. Pharm Thesis Writing Services: A Comprehensive Guide
- Sample Thesis for M. Pharm Project: Download thesis Sample Format