Pharmaceutics GPAT Mock test/Quiz for 50 Question Mock Test and Quiz: Welcome to Witfire’s specialized Pharmaceutics GPAT Mock Test/Quiz, engineered for those aiming for excellence in the GPAT exam. Comprising 50 incisive questions, this mock test covers the breadth and depth of pharmaceutics, offering targeted practice for GPAT aspirants.
Focused Question Set
Our 50-question mock test in Pharmaceutics zeroes in on vital topics such as dosage forms, drug delivery systems, and pharmaceutical technology, providing a robust platform for concentrated study and practice.
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Timely and Relevant
Aligned with current industry practices and research, the 50-question mock test keeps you abreast of the latest trends and updates in the field of Pharmaceutics.
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The 50 questions have been crafted to fit snugly into shorter yet effective study sessions, letting you evaluate your readiness in the Pharmaceutics domain for the GPAT exam in an efficient manner.
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Pharmaceutics GPAT Mock test I/Quiz for 50 Question Mock Test and Quiz
#1. Which of the following mechanisms describes the release of drug from a porous matrix?
Higuchi Equation #2. The study of how dosage forms interact with the body is termed as:
Pharmacokinetics #3. Which is the most commonly used preservative in ophthalmic preparations?
Parabens #4. Which equation is commonly employed for dissolution studies of pharmaceuticals?
Arrhenius equation #5. Which process involves reduction of particle size in a solid substance?
#6. What is the chief active ingredient in effervescent tablets?
Aluminum Hydroxide #7. What is the ideal osmolarity of intravenous solutions relative to blood?
None of the above #8. Which polymer is extensively used in the formulation of hydrogel drug delivery systems?
Hyaluronic Acid #9. What is the principal rationale behind enteric coating of tablets?
To mask taste
To enhance dissolution
To bypass stomach acid
To sustain drug release #10. In HPLC, what does the term "mobile phase" refer to?
The column material
The solvent system
The detector component
The injected sample
#11. Which of the following is a technique for the bottom-up approach in nanoparticle synthesis?
Co-precipitation #12. Which type of tablet is designed to float on gastric fluid?
Gastroretentive Tablets #13. Which drug formulation technique aims to enhance solubility by reducing particle size to the submicron level?
Hot Melt Extrusion #14. What is the key variable in determining the viscosity of a Newtonian fluid?
Pressure #15. Which of the following is a primary packaging material for parenteral formulations?
Type I Glass
#16. What is the mechanism of action of osmotic controlled-release oral delivery systems (OROS)?
Solubilization #17. Which method is commonly used for sterilization of thermolabile solutions?
Dry heat sterilization
Radiation #18. Which of the following excipients acts as a glidant in tablet formulations?
Starch #19. What parameter is analyzed in the friability test of tablets?
Cohesiveness #20. Which among the following is a common method for enhancing the bioavailability of poorly water-soluble drugs?
#21. Which isomerism is most critical in the pharmacokinetic properties of drugs?
Tautomeric Isomerism #22. What is the critical micelle concentration (CMC) primarily dependent upon?
Ionic strength of the solution
Hydrophobic tail length
pH of the solution #23. Which technique involves the use of X-rays to measure the particle size distribution?
Dynamic Light Scattering
Coulter Counter #24. Which mathematical model is used to describe non-Fickian (anomalous) drug release from polymeric systems?
Higuchi Equation #25. Which of the following is NOT a parameter in the design space as per Quality by Design (QbD) framework?
Critical Quality Attributes
Critical Process Parameters
#26. In Quality Risk Management, which of the following methods is a quantitative approach?
FMEA (Failure Modes and Effects Analysis)
SWIFT (Structured What-If Technique) #27. What is the critical parameter that dictates the stability of a lyophilized product?
Glass Transition Temperature
Residual Solvent Content
Protein Aggregation #28. In a SEDDS (Self-Emulsifying Drug Delivery System), what does the term 'Self-Emulsifying' signify?
Presence of surfactant
Formation of micelles #29. Which polymorphic form of a drug is usually the most stable?
Hexagonal #30. What is the role of P-glycoprotein in drug absorption?
Facilitates passive diffusion
Acts as an efflux pump
Facilitates active transport
#31. Which equation describes the relationship between dissolution rate and solubility in a sparingly soluble drug under sink conditions?
Noyes-Whitney Equation modified by Hixson-Crowell
Ostwald's Rule of Stages
Higuchi Equation with sink conditions #32. What is the inherent challenge in the formulation of protein-based drugs?
Ostwald Ripening #33. Which of the following parameters is NOT generally considered in the Development and Scale-Up of a freeze-drying process?
Glass Transition Temperature
Zeta Potential #34. In Targeted Drug Delivery, what role does PEGylation play?
Facilitates enzyme catalyzed release
Increases cellular uptake
Enhances drug solubility
Reduces immunogenicity and extends half-life #35. What is the principle behind the use of cyclodextrins in drug formulations?
Formation of covalent bonds
Formation of inclusion complexes
#36. Which of the following techniques would be most appropriate for particle size reduction to the nanometer range?
Coacervation #37. What does 'Q3' signify in a Q1/Q2/Q3 sameness test for generic drugs?
Quality of excipients
Drug release profile #38. Which among the following is a correct method to study 'Polymorphism' in drug substances?
Differential Scanning Calorimetry (DSC)
Karl Fischer Titration
Fourier Transform Infrared Spectroscopy (FTIR) only #39. Which Quality by Design (QbD) element refers to the attributes that should be within an appropriate limit, range, or distribution to ensure the desired product quality?
Critical Material Attributes (CMA)
Quality Target Product Profile (QTPP)
Critical Quality Attributes (CQA)
Critical Process Parameters (CPP) #40. In Nanotechnology-based drug delivery, what is the major advantage of Lipid-Based Nanocarriers?
Ability to load both hydrophilic and hydrophobic drugs
Controlled release up to several weeks
#41. What is the mathematical basis for determining shelf-life through accelerated stability testing?
Michaelis-Menten Kinetics #42. Which of the following methods would be most suitable for the determination of residual solvents in a drug substance?
High-Performance Liquid Chromatography (HPLC)
NMR Spectroscopy #43. How does iontophoresis facilitate transdermal drug delivery?
By reducing skin resistance
By facilitating active transport
By altering pH at the skin surface
By applying an electric current #44. Which mechanism is primarily involved in the release of drug from an osmotically controlled pump?
Diffusion through a semi-permeable membrane
Erosion of the polymeric matrix
Swelling and dissolution of the rate-controlling membrane
Osmotic pressure gradient #45. Which principle is applied in the measurement of particle size through laser diffraction?
#46. Which is NOT a typical characteristic of a supercritical fluid?
High surface tension
Tunable solvent power #47. What does the Peppas-Sahlin model describe?
Purely Fickian diffusion
Purely non-Fickian diffusion
Coupled Fickian diffusion and relaxation mechanism
Swelling-controlled release #48. Which of the following surfactants is generally used in parenteral formulations?
Sodium Lauryl Sulfate
Benzalkonium Chloride #49. In a phase diagram for a pharmaceutical emulsion, what does the Bancroft rule primarily dictate?
Type of emulsion
Stability of emulsion
Optimal concentration of emulsifier
Phase inversion temperature #50. What is the main purpose of a 'geriatric' formulation?
To increase drug bioavailability
To provide taste masking
To provide ease of swallowing
To ensure controlled release